Relationship of serum lipid parameters with kidney function decline accompanied by systemic arterial stiffness: a retrospective cohort study

ABSTRACT Background Dyslipidemia is associated with kidney function decline (KFD), although the non-linear relationship of lipid parameters to KFD has not been fully elucidated. We aimed determine detailed baseline KFD, considering mediation arterial stiffness. Methods A total 27 864 urban residents estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 at baseline, who participated in a median three (range two eight) consecutive annual health examinations were studied. Arterial stiffness was assessed by cardio-ankle vascular index (CAVI). defined as development eGFR <60 m2. Results During study period, 1837 participants (6.6%) developed KFD. Receiver operating characteristic analysis determined that cutoff values independently are 123 mg/dL for low-density lipoprotein cholesterol (LDL-C) [area under curve (95% confidence interval) 0.570 (0.557–0.583)], 65 high-density (HDL-C) [0.552 (0.539–0.566)], 82 triglycerides (TG) [0.606 (0.593–0.618)] and 1.28 TG/HDL-C ratio [0.600 (0.587–0.612)]. These cut-offs Cox analysis. Regarding contribution each parameter linear observed both TG TG/HDL-C, U-shaped HDL-C. adjusted mediating effect CAVI on or (mediating rate: 2.9% TG, 2.5% ratio). association after adjustment confounders. Conclusions related linearly this partially mediated CAVI. between HDL-C risk. LDL-C showed no significant association. Further should investigate whether intensive TG-lowering treatment prevents via decreasing